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ReproductiveICD-10: O14Affects 3–8% of all pregnancies worldwide

Preeclampsia

Also known as: Toxemia of Pregnancy, Pregnancy-Induced Hypertension (related)

Preeclampsia is a serious pregnancy complication characterized by high blood pressure and signs of organ damage, most often affecting the liver and kidneys, typically developing after 20 weeks of gestation. Without treatment, it can progress to eclampsia (seizures) or HELLP syndrome, both of which are life-threatening. Delivery of the baby and placenta is the only definitive treatment, making timing of delivery a critical clinical decision.

Symptoms

High blood pressure (≥140/90 mmHg on two occasions)
Protein in the urine (proteinuria)
Severe headaches not relieved by medication
Visual disturbances (blurred vision, light sensitivity, seeing spots)
Upper abdominal pain, especially under the right ribs
Sudden weight gain and facial/hand swelling (edema)
Nausea or vomiting in the second half of pregnancy
Decreased urine output
Shortness of breath (due to fluid in the lungs)

Causes

  • Abnormal placental development and impaired blood vessel remodeling
  • Placental factors releasing substances causing systemic vascular dysfunction
  • Immune and inflammatory factors
  • Genetic predisposition

Risk Factors

  • First pregnancy (nulliparity)
  • History of preeclampsia in a prior pregnancy
  • Chronic hypertension or kidney disease
  • Obesity (BMI >30)
  • Multiple gestation (twins, triplets)
  • Age over 35 or under 20

Diagnosis

  • Blood pressure ≥140/90 mmHg after 20 weeks of gestation
  • Urine protein-to-creatinine ratio or 24-hour urine protein collection
  • Blood tests: liver enzymes, platelet count, creatinine, LDH
  • Fetal monitoring (non-stress test, biophysical profile, ultrasound for growth)

Treatment

  • Delivery of the baby (definitive treatment, timing depends on severity and gestational age)
  • Antihypertensive medications (labetalol, nifedipine, hydralazine)
  • Magnesium sulfate for seizure prevention (eclampsia prophylaxis)
  • Corticosteroids if delivery is needed before 37 weeks (for fetal lung maturity)
  • Close monitoring in hospital for severe preeclampsia

Prevention

  • Low-dose aspirin (81 mg daily) starting at 12 weeks for women at high risk (ACOG recommendation)
  • Calcium supplementation in women with low dietary calcium intake
  • Regular prenatal care with blood pressure monitoring
  • Maintaining a healthy weight before pregnancy

When to See a Doctor

  • Sudden swelling of hands or face
  • Severe headache that does not resolve with rest or acetaminophen
  • Visual changes during pregnancy (blurring, spots, flashing lights)
  • Severe upper abdominal pain

Frequently Asked Questions

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