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InfectiousICD-10: A35About 30 cases reported annually in the US due to high vaccination rates

Tetanus

Also known as: Lockjaw

Tetanus is a serious bacterial infection caused by Clostridium tetani that produces a toxin affecting the nervous system, leading to painful muscle stiffness and spasms, particularly in the jaw and neck. The bacteria enter the body through wounds, and the disease is preventable with vaccination. Tetanus is a medical emergency requiring immediate treatment.

Symptoms

Jaw stiffness and difficulty opening the mouth (lockjaw)
Stiffness in the neck and abdominal muscles
Difficulty swallowing
Painful muscle spasms triggered by minor stimuli
Fever and sweating
Elevated blood pressure and rapid heart rate
Body rigidity

Causes

  • Infection with Clostridium tetani bacteria through wounds
  • Tetanus toxin (tetanospasmin) blocking nerve signals to muscles
  • Contamination of puncture wounds, burns, or crush injuries with soil or feces

Risk Factors

  • Lack of vaccination or incomplete vaccination series
  • Puncture wounds or deep cuts
  • Burns or crush injuries
  • Intravenous drug use
  • Failure to receive booster shots every 10 years

Diagnosis

  • Clinical diagnosis based on symptoms and wound history
  • Spatula test showing masseter spasm when touching the throat
  • No reliable laboratory test for confirmation
  • Blood tests may show elevated muscle enzymes

Treatment

  • Tetanus immune globulin to neutralize circulating toxin
  • Antibiotics such as metronidazole to kill the bacteria
  • Wound debridement and cleaning
  • Muscle relaxants and sedatives for spasm control
  • Supportive care in an ICU setting with mechanical ventilation if needed
  • Tetanus vaccination after recovery to prevent recurrence

Prevention

  • DTaP vaccine series in childhood
  • Tdap booster for adolescents and adults
  • Td booster every 10 years
  • Proper wound care including cleaning and seeking medical attention for deep wounds

When to See a Doctor

  • Deep or dirty wound especially if vaccination status is uncertain
  • Jaw stiffness or difficulty opening the mouth
  • Muscle spasms following a wound
  • Any wound caused by a rusty or contaminated object

Frequently Asked Questions

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