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InfectiousICD-10: A41.9At least 1.7 million adults develop sepsis each year in the US

Sepsis

Also known as: Blood poisoning, Septicemia, Systemic inflammatory response syndrome

Sepsis is a life-threatening medical emergency that occurs when the body's response to an infection spirals out of control, leading to widespread inflammation and organ damage. It can progress rapidly to septic shock with dangerously low blood pressure. Early recognition and prompt treatment with antibiotics and supportive care are critical for survival.

Symptoms

High fever or abnormally low temperature
Rapid heart rate
Rapid breathing
Confusion or disorientation
Extreme pain or discomfort
Clammy or sweaty skin
Low blood pressure
Decreased urine output
Mottled or discolored skin

Causes

  • Bacterial infections are the most common cause
  • Viral infections including influenza and COVID-19
  • Fungal infections in immunocompromised individuals
  • Infections originating in the lungs, urinary tract, abdomen, or bloodstream

Risk Factors

  • Age over 65 or under 1 year
  • Weakened immune system from chronic disease or medications
  • Recent surgery or hospitalization
  • Chronic conditions such as diabetes, kidney disease, or cancer
  • Indwelling medical devices such as catheters or IV lines

Diagnosis

  • Blood cultures to identify the causative organism
  • Complete blood count and lactate levels
  • Procalcitonin and C-reactive protein tests
  • Imaging studies to locate the source of infection
  • qSOFA and SOFA scoring systems for severity assessment

Treatment

  • Immediate broad-spectrum intravenous antibiotics
  • Aggressive intravenous fluid resuscitation
  • Vasopressors to maintain blood pressure in septic shock
  • Organ support including mechanical ventilation or dialysis
  • Source control such as draining abscesses or removing infected devices
  • ICU monitoring and care

Prevention

  • Prompt treatment of infections before they spread
  • Proper wound care and hygiene
  • Staying up to date with vaccinations
  • Practicing good hand hygiene in healthcare settings

When to See a Doctor

  • Fever with confusion or rapid breathing
  • Symptoms of infection that are rapidly worsening
  • Feeling like you might die from an infection
  • Mottled skin or extreme drop in blood pressure

Frequently Asked Questions

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Medical Disclaimer: This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider.

Content reviewed against peer-reviewed medical literature and clinical guidelines. Read our editorial standards.