Amenorrhea
Also known as: Absent periods, Missed periods
Amenorrhea means the absence of menstrual periods. Primary amenorrhea is when periods have not started by around age 15 or 16, while secondary amenorrhea is when periods that were previously regular stop for three months or more (or six months if cycles were irregular). It is normal during pregnancy, breastfeeding, and after menopause, but outside those situations it usually signals that something is interrupting the hormonal signals between the brain, the ovaries, and the uterus. Common causes include stress, significant weight change, intense exercise, polycystic ovary syndrome, and thyroid problems. Identifying the cause matters, because long periods without estrogen can affect bone health and fertility.
At a Glance
- Common symptoms
- No menstrual period for three or more months (or none by age 15–16), Milky nipple discharge not related to breastfeeding, Headaches or vision changes (if a pituitary cause is involved)
- Main treatments
- Treating the underlying cause, such as thyroid medication for hypothyroidism, Hormonal therapy (combined pills or cyclic progesterone) to restore cycles and protect bones when appropriate, Medication to lower prolactin if a pituitary tumor is responsible
- Category
- Reproductive · Common; secondary amenorrhea in particular affects many women at some point outside pregnancy and menopause
- See a doctor if
- You have missed three periods in a row and are not pregnant
Symptoms
Causes
- Natural causes such as pregnancy, breastfeeding, and menopause
- Hormonal contraceptives and some medications (antipsychotics, antidepressants, chemotherapy)
- Low body weight, eating disorders, or very intense exercise
- Polycystic ovary syndrome (PCOS) and thyroid disorders
- Pituitary problems such as a prolactin-producing tumor
- Structural issues such as uterine scarring or, in primary cases, genetic or developmental differences
Risk Factors
- Significant psychological stress
- Rapid or substantial weight loss or gain
- Elite or endurance athletic training
- Family history of early menopause or delayed puberty
- Prior uterine surgery or procedures
Diagnosis
- Pregnancy test, which is always the first step
- Medical history covering weight, exercise, stress, medications, and menstrual pattern
- Blood tests for thyroid function, prolactin, FSH, LH, estrogen, and androgens
- Pelvic ultrasound to look at the ovaries and uterus
- Brain (pituitary) MRI if prolactin is high or other signs point to the pituitary
Treatment
- Treating the underlying cause, such as thyroid medication for hypothyroidism
- Hormonal therapy (combined pills or cyclic progesterone) to restore cycles and protect bones when appropriate
- Medication to lower prolactin if a pituitary tumor is responsible
- Fertility treatments if pregnancy is desired
- Surgery for structural problems such as uterine scarring
- Supportive: restoring adequate nutrition and body weight with professional help if weight or eating is the trigger
- Supportive: moderating exercise intensity and building stress-management habits where these are contributing
Prevention
- Maintain a healthy, stable body weight
- Balance intense training with enough energy intake and rest
- Manage stress with sleep, relaxation practices, and support
- Track your cycles so you notice changes early
- Review medications that may affect periods with your doctor
When to See a Doctor
- You have missed three periods in a row and are not pregnant
- You are 15 or older and have never had a period
- Missed periods come with headaches, vision changes, or nipple discharge
- Absent periods are accompanied by significant weight loss or disordered eating
- You are trying to conceive and your cycles have stopped
Frequently Asked Questions
Related Conditions
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