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ReproductiveICD-10: N95.1Affects all women, typically between ages 45 and 55; about 1.3 million US women reach menopause annually

Menopause

Also known as: Change of Life, Climacteric

Menopause is a natural biological process marking the permanent end of menstrual periods, diagnosed after 12 consecutive months without menstruation. It typically occurs between ages 45 and 55, with the average age being 51 in the United States. The transition involves declining estrogen and progesterone levels that can cause a range of physical and emotional symptoms.

Symptoms

Hot flashes and night sweats
Irregular periods during perimenopause
Vaginal dryness and discomfort during intercourse
Sleep disturbances and insomnia
Mood changes including irritability and depression
Weight gain and slowed metabolism
Thinning hair and dry skin
Decreased libido
Memory difficulties and brain fog
Joint pain and stiffness

Causes

  • Natural age-related decline in ovarian function
  • Surgical removal of both ovaries (bilateral oophorectomy)
  • Chemotherapy or pelvic radiation therapy
  • Primary ovarian insufficiency (premature menopause)

Risk Factors

  • Age approaching the late 40s to early 50s
  • Smoking (associated with earlier menopause)
  • Family history of early menopause
  • History of hysterectomy
  • Autoimmune conditions affecting the ovaries

Diagnosis

  • Clinical evaluation based on age and symptom history
  • Follicle-stimulating hormone (FSH) blood test (elevated in menopause)
  • Estradiol level testing (decreased in menopause)
  • Thyroid function tests to rule out thyroid disorders

Treatment

  • Hormone replacement therapy (HRT) with estrogen and/or progesterone
  • Low-dose vaginal estrogen for urogenital symptoms
  • Non-hormonal medications (SSRIs, gabapentin, clonidine) for hot flashes
  • Vaginal moisturizers and lubricants
  • Cognitive behavioral therapy for mood and sleep symptoms
  • Calcium, vitamin D, and weight-bearing exercise for bone health

Prevention

  • Menopause itself cannot be prevented, but symptoms can be managed
  • Regular exercise to support mood and bone density
  • Balanced diet rich in calcium and phytoestrogens
  • Avoid smoking, which may hasten menopause

When to See a Doctor

  • Heavy or prolonged bleeding during perimenopause
  • Bleeding after 12 months without a period
  • Symptoms significantly impacting quality of life
  • Concerns about bone density or cardiovascular risk

Frequently Asked Questions

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Content reviewed against peer-reviewed medical literature and clinical guidelines. Read our editorial standards.