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MusculoskeletalICD-10: M81About 10 million Americans have osteoporosis; 44 million have low bone density

Osteoporosis

Also known as: Brittle Bone Disease (colloquial), Low Bone Density

Osteoporosis is a systemic skeletal disorder characterized by decreased bone density and deterioration of bone microarchitecture, leading to increased bone fragility and fracture risk. Often called a 'silent disease,' osteoporosis typically has no symptoms until a fracture occurs. The most common fracture sites are the spine, hip, and wrist, and hip fractures in particular carry significant mortality risk in older adults.

Symptoms

Often asymptomatic until a fracture occurs
Loss of height over time
Stooped posture (kyphosis or dowager's hump)
Back pain from vertebral compression fractures
Fracture from a fall or even a minor bump
Receding gums and tooth loss (may indicate bone loss)

Causes

  • Imbalance between bone resorption and bone formation favoring net bone loss
  • Declining estrogen levels after menopause (most common cause in women)
  • Aging-related decrease in osteoblast activity
  • Secondary causes: corticosteroid use, hyperthyroidism, hyperparathyroidism, celiac disease

Risk Factors

  • Female sex and postmenopausal status
  • Age over 50
  • Family history of osteoporosis or hip fracture
  • Small, thin body frame
  • Low calcium and vitamin D intake
  • Sedentary lifestyle

Diagnosis

  • Dual-energy X-ray absorptiometry (DEXA) scan measuring bone mineral density
  • FRAX score calculation to assess 10-year fracture risk
  • Blood tests (calcium, vitamin D, thyroid function, parathyroid hormone)
  • Vertebral fracture assessment via lateral spine X-ray or DEXA

Treatment

  • Bisphosphonates (alendronate, risedronate, zoledronic acid) — first-line therapy
  • Denosumab (RANK ligand inhibitor)
  • Anabolic agents (teriparatide, romosozumab) for severe osteoporosis
  • Hormone replacement therapy (for menopausal women with other indications)
  • Adequate calcium (1,200 mg/day) and vitamin D (800–1,000 IU/day) supplementation
  • Weight-bearing and resistance exercises

Prevention

  • Engage in regular weight-bearing and muscle-strengthening exercises
  • Ensure adequate calcium and vitamin D intake through diet and supplementation
  • Avoid smoking and excessive alcohol consumption
  • Undergo bone density screening as recommended (women at 65, men at 70, or earlier with risk factors)
  • Fall prevention strategies including home safety modifications

When to See a Doctor

  • Fracture from a low-impact fall or minimal trauma
  • Loss of height or developing a stooped posture
  • Back pain that may indicate a vertebral fracture
  • Postmenopausal or age-related risk factors warranting bone density screening

Frequently Asked Questions

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