Osteoporosis
Also known as: Brittle Bone Disease (colloquial), Low Bone Density
Osteoporosis is a systemic skeletal disorder characterized by decreased bone density and deterioration of bone microarchitecture, leading to increased bone fragility and fracture risk. Often called a 'silent disease,' osteoporosis typically has no symptoms until a fracture occurs. The most common fracture sites are the spine, hip, and wrist, and hip fractures in particular carry significant mortality risk in older adults.
Symptoms
Causes
- Imbalance between bone resorption and bone formation favoring net bone loss
- Declining estrogen levels after menopause (most common cause in women)
- Aging-related decrease in osteoblast activity
- Secondary causes: corticosteroid use, hyperthyroidism, hyperparathyroidism, celiac disease
Risk Factors
- Female sex and postmenopausal status
- Age over 50
- Family history of osteoporosis or hip fracture
- Small, thin body frame
- Low calcium and vitamin D intake
- Sedentary lifestyle
Diagnosis
- Dual-energy X-ray absorptiometry (DEXA) scan measuring bone mineral density
- FRAX score calculation to assess 10-year fracture risk
- Blood tests (calcium, vitamin D, thyroid function, parathyroid hormone)
- Vertebral fracture assessment via lateral spine X-ray or DEXA
Treatment
- Bisphosphonates (alendronate, risedronate, zoledronic acid) — first-line therapy
- Denosumab (RANK ligand inhibitor)
- Anabolic agents (teriparatide, romosozumab) for severe osteoporosis
- Hormone replacement therapy (for menopausal women with other indications)
- Adequate calcium (1,200 mg/day) and vitamin D (800–1,000 IU/day) supplementation
- Weight-bearing and resistance exercises
Prevention
- Engage in regular weight-bearing and muscle-strengthening exercises
- Ensure adequate calcium and vitamin D intake through diet and supplementation
- Avoid smoking and excessive alcohol consumption
- Undergo bone density screening as recommended (women at 65, men at 70, or earlier with risk factors)
- Fall prevention strategies including home safety modifications
When to See a Doctor
- Fracture from a low-impact fall or minimal trauma
- Loss of height or developing a stooped posture
- Back pain that may indicate a vertebral fracture
- Postmenopausal or age-related risk factors warranting bone density screening
Frequently Asked Questions
Related Conditions
Related from the Supplement Library
Calcium
StrongMineral · Bone and dental health (99% of body calcium)
Vitamin D
StrongVitamin · Bone health and calcium absorption
Vitamin K2
ModerateVitamin · Bone mineralization via osteocalcin activation
Magnesium Glycinate
StrongMineral · Improves sleep quality and onset
These supplements have been studied in relation to Osteoporosis. Always consult your healthcare provider before starting any supplement, especially if you take medications.
Have questions about Osteoporosis?
Ask Mother Nature AI for personalized, evidence-based guidance.
Ask about OsteoporosisMedical Disclaimer: This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider.
Content reviewed against peer-reviewed medical literature and clinical guidelines. Read our editorial standards.