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VitaminModerate Evidence

Vitamin K2

Menaquinone

The underappreciated partner to Vitamin D3, K2 activates proteins that direct calcium to bones and teeth while preventing dangerous arterial calcification.

Known Health Benefits

Bone mineralization via osteocalcin activation
Cardiovascular health — prevents arterial calcification
Works synergistically with Vitamin D3
May reduce osteoporosis risk

Active Compounds

MK-4, MK-7 (menaquinones)

Dosage Guidance

100–200 mcg MK-7 daily

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

Generally very safe; GI discomfort rare

Known Drug Interactions

MAJOR interaction with warfarin and other blood thinners — must monitor INR

Evidence Classification

Moderate Evidence

Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.

Related Entries

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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.