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InfectiousICD-10: A54.9Approximately 1.6 million new infections occur annually in the United States

Gonorrhea

Also known as: The Clap, Gonococcal Infection

Gonorrhea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae. It can infect the genitals, rectum, and throat and is transmitted through vaginal, anal, or oral sex. If untreated, gonorrhea can cause serious complications including pelvic inflammatory disease, infertility, and disseminated gonococcal infection.

Symptoms

Thick, cloudy, or bloody discharge from the penis or vagina
Painful or burning sensation during urination
Increased vaginal discharge or bleeding between periods
Painful or swollen testicles in men
Rectal pain, discharge, or bleeding
Sore throat if pharyngeal infection is present
Many women and some men are asymptomatic

Causes

  • Infection with Neisseria gonorrhoeae bacterium
  • Transmitted through unprotected vaginal, anal, or oral sex
  • Can be transmitted from mother to newborn during childbirth

Risk Factors

  • Age 15–24 — highest incidence age group
  • Multiple sexual partners
  • Inconsistent condom use
  • Previous gonorrhea or other STI diagnosis
  • Men who have sex with men

Diagnosis

  • Nucleic acid amplification test (NAAT) on urine or swab samples
  • Gram stain of urethral discharge showing gram-negative intracellular diplococci
  • Culture and sensitivity testing to guide antibiotic selection
  • Testing for co-infections (chlamydia, HIV, syphilis)

Treatment

  • Dual antibiotic therapy: intramuscular ceftriaxone as primary treatment
  • Test of cure recommended 7–14 days after treatment for pharyngeal infections
  • Treatment of all sexual partners from the prior 60 days
  • Abstinence from sexual contact until treatment is completed and symptoms resolve

Prevention

  • Consistent and correct condom use for all sexual encounters
  • Regular STI screening for sexually active individuals
  • Mutual monogamy with a tested, uninfected partner
  • Prompt treatment of infected individuals and their partners

When to See a Doctor

  • Unusual genital discharge, pain during urination, or genital sores
  • A sexual partner has been diagnosed with gonorrhea or another STI
  • Routine STI screening is due based on sexual activity and risk factors
  • Symptoms of disseminated infection such as joint pain, skin lesions, or fever

Frequently Asked Questions

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