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EndocrineICD-10: E05Affects about 1.2% of the U.S. population

Hyperthyroidism

Also known as: Overactive Thyroid, Thyrotoxicosis

Hyperthyroidism is a condition in which the thyroid gland produces too much thyroid hormone, accelerating metabolism and affecting virtually every organ system. The most common cause is Graves' disease. Treatment is highly effective and may include medication, radioactive iodine, or surgery.

Symptoms

Unexplained weight loss despite increased appetite
Rapid or irregular heartbeat
Anxiety, nervousness, and irritability
Tremor of hands and fingers
Increased sweating and heat intolerance
Changes in menstrual patterns
Frequent bowel movements
Enlarged thyroid (goiter)
Fatigue and muscle weakness
Difficulty sleeping

Causes

  • Graves' disease (most common — autoimmune)
  • Toxic multinodular goiter
  • Toxic adenoma (single hyperfunctioning nodule)
  • Thyroiditis (inflammation releasing stored hormone)
  • Excessive iodine or thyroid medication

Risk Factors

  • Female sex
  • Family history of thyroid disorders
  • History of autoimmune diseases
  • Recent pregnancy (postpartum thyroiditis)
  • Excessive iodine intake

Diagnosis

  • Blood tests: low TSH, elevated free T4 and/or T3
  • Thyroid antibody tests (TSI, TRAb for Graves')
  • Radioactive iodine uptake and scan
  • Thyroid ultrasound to evaluate nodules

Treatment

  • Anti-thyroid medications (methimazole, propylthiouracil)
  • Radioactive iodine therapy
  • Beta-blockers for rapid symptom relief
  • Thyroidectomy for certain cases
  • Lifelong thyroid hormone replacement after radioiodine or surgery

Prevention

  • No known prevention for most causes
  • Avoid excessive iodine supplementation
  • Regular monitoring if you have risk factors

When to See a Doctor

  • Unexplained weight loss with rapid heartbeat
  • Symptoms of anxiety, tremor, and heat intolerance are new or worsening
  • You develop a visible neck swelling
  • Palpitations or irregular heartbeat occur

Frequently Asked Questions

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