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MetabolicICD-10: D50Affects approximately 10 million people in the U.S.; most common nutritional deficiency worldwide

Iron Deficiency Anemia

Also known as: IDA, Low Iron, Anemia from Iron Deficiency

Iron deficiency anemia is the most common type of anemia worldwide, occurring when the body lacks sufficient iron to produce adequate hemoglobin. Without enough hemoglobin, tissues and organs don't get enough oxygen. It is most prevalent in women of reproductive age, children, and people with chronic blood loss.

Symptoms

Fatigue and weakness
Pale skin, gums, and nail beds
Shortness of breath with exertion
Dizziness or lightheadedness
Cold hands and feet
Brittle nails or spoon-shaped nails (koilonychia)
Unusual cravings for non-food items (pica)
Headaches
Rapid or irregular heartbeat
Restless legs syndrome

Causes

  • Blood loss from heavy menstruation
  • GI bleeding (ulcers, polyps, colorectal cancer)
  • Insufficient dietary iron intake
  • Impaired iron absorption (celiac disease, gastric bypass, H. pylori)
  • Increased iron needs during pregnancy or rapid growth

Risk Factors

  • Women of reproductive age
  • Pregnancy
  • Vegetarian or vegan diets without adequate iron sources
  • Frequent blood donation
  • Chronic GI conditions
  • Infants and young children

Diagnosis

  • CBC showing low hemoglobin and small, pale red blood cells
  • Serum ferritin (most sensitive test for iron stores)
  • Serum iron and total iron-binding capacity (TIBC)
  • Peripheral blood smear
  • Evaluation for source of blood loss if cause is unclear

Treatment

  • Oral iron supplements with vitamin C to enhance absorption
  • Intravenous iron infusion for severe deficiency or oral intolerance
  • Dietary changes to increase iron-rich foods
  • Treatment of underlying cause of blood loss
  • Blood transfusion for severe, symptomatic anemia

Prevention

  • Eat iron-rich foods regularly (lean meats, seafood, beans, dark leafy greens)
  • Pair iron-rich foods with vitamin C sources
  • Avoid tea or coffee with meals (inhibits absorption)
  • Consider iron supplementation during pregnancy

When to See a Doctor

  • Persistent fatigue, weakness, or pale skin
  • Heavy menstrual periods or blood in your stool
  • You are pregnant and have not been screened
  • Symptoms are affecting daily activities

Frequently Asked Questions

Related Conditions

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