ReproductiveICD-10: N48.6More common than once thought, particularly in middle-aged men; often underreported

Peyronie's Disease

Also known as: Peyronie disease, Penile fibrosis, Curved penis

Peyronie's disease is a condition in which scar tissue (plaque) forms in the tough sheath surrounding the erectile tissue of the penis. The plaque does not stretch like normal tissue, so during an erection the penis bends, narrows, or develops an indentation at the site of the scar. It typically begins with pain and a gradually developing curve during an active phase that lasts several months, then settles into a stable phase where pain eases but the curvature remains. Peyronie's can make sex difficult or impossible and often causes considerable distress and loss of confidence. It is believed to result from abnormal healing after minor injuries to the penis, and treatments range from injections and traction to surgery, depending on severity and stage.

At a Glance

Common symptoms
A hard lump or band of tissue that can be felt under the skin of the penis, A curve, bend, or hourglass narrowing of the penis during erection, Pain in the penis, with or without an erection, especially in the early active phase
Main treatments
Observation during the active phase, since surgery is not performed until the condition has been stable for several months, Collagenase injections (Xiaflex) into the plaque, which break down scar tissue and reduce curvature in suitable candidates, Penile traction therapy using a device worn daily, which can reduce curvature and preserve length
Category
Reproductive · More common than once thought, particularly in middle-aged men; often underreported
See a doctor if
A new lump, curve, or indentation in the penis

Symptoms

A hard lump or band of tissue that can be felt under the skin of the penis
A curve, bend, or hourglass narrowing of the penis during erection
Pain in the penis, with or without an erection, especially in the early active phase
Shortening of the penis
Difficulty with penetration or painful intercourse
Erectile dysfunction
Anxiety, low mood, or relationship stress related to the condition

Causes

  • Abnormal wound healing after repeated minor trauma to the erect penis during sex or sport, often not remembered
  • Formation of fibrous scar tissue in the tunica albuginea, the sheath around the erectile chambers
  • A genetic predisposition to abnormal scarring
  • Association with connective tissue disorders such as Dupuytren's contracture of the hand

Risk Factors

  • Middle age, with most diagnoses between 40 and 70
  • A family history of Peyronie's disease or Dupuytren's contracture
  • Diabetes and erectile dysfunction
  • Previous prostate surgery
  • Smoking and a history of pelvic or penile trauma

Diagnosis

  • A history of symptoms, timing, and effect on sexual function
  • Physical examination to feel the plaque and assess its location and size
  • Assessment of the curvature, sometimes using photographs taken at home during erection or an injection-induced erection in clinic
  • Penile ultrasound to map the plaque and check blood flow
  • Screening for erectile dysfunction and psychological distress

Treatment

  • Observation during the active phase, since surgery is not performed until the condition has been stable for several months
  • Collagenase injections (Xiaflex) into the plaque, which break down scar tissue and reduce curvature in suitable candidates
  • Penile traction therapy using a device worn daily, which can reduce curvature and preserve length
  • Oral medications for pain or erectile dysfunction; drugs such as pentoxifylline have limited evidence for the plaque itself
  • Surgery for stable, significant curvature: plication (shortening the longer side), grafting of the plaque, or penile implant when erectile dysfunction coexists
  • Supportive: counseling or sex therapy to address distress and help couples adapt
  • Supportive: vitamin E and other supplements have been widely used but trials show little benefit; discuss before trying

Prevention

  • Peyronie's cannot be reliably prevented
  • Take care during vigorous sex to avoid bending injuries to the erect penis
  • Treat erectile dysfunction, since a partially rigid penis is more vulnerable to buckling injuries
  • Keep diabetes well controlled and do not smoke
  • Seek assessment early when a curve or lump appears, since early treatment options differ from late ones

When to See a Doctor

  • A new lump, curve, or indentation in the penis
  • Pain with erections lasting more than a few weeks
  • Curvature that makes sex difficult or painful
  • Sudden severe pain, bruising, and swelling of the penis after a 'popping' sensation during sex (emergency, possible penile fracture)
  • Significant distress or relationship strain related to the condition

Frequently Asked Questions

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