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CompoundStrong Evidence

CoQ10 (Ubiquinone)

A coenzyme essential for mitochondrial ATP production and a potent fat-soluble antioxidant. Especially important for anyone taking statins, which deplete endogenous CoQ10 levels.

Known Health Benefits

Mitochondrial energy production (ATP)
Heart health and cardiac function
Antioxidant protection in cell membranes
May reduce statin-associated muscle symptoms

Active Compounds

Ubiquinone (oxidized), ubiquinol (reduced, active form)

Dosage Guidance

100–300 mg daily (ubiquinol form for those over 40)

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

Mild GI upset, insomnia if taken too late; generally well tolerated

Known Drug Interactions

May interact with blood thinners and blood pressure medications; statins deplete CoQ10

Evidence Classification

Strong Evidence

Supported by randomized controlled trials (RCTs), systematic reviews, or meta-analyses published in peer-reviewed journals.

Related Entries

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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.