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Mental HealthICD-10: F19Over 20 million Americans have a substance use disorder; about 10% of adults experience it in their lifetime

Substance Use Disorder

Also known as: Addiction, Drug addiction, Substance abuse

Substance use disorder is a chronic brain condition characterized by the compulsive use of substances such as alcohol, drugs, or medications despite harmful consequences. It involves changes in brain circuits related to reward, stress, and self-control that can persist long after substance use stops. Recovery is achievable through a combination of behavioral therapies, medications, and ongoing support.

Symptoms

Inability to control or stop substance use despite wanting to
Craving or strong urge to use the substance
Continued use despite negative effects on health, relationships, or work
Needing more of the substance to achieve the same effect (tolerance)
Withdrawal symptoms when not using the substance
Spending significant time obtaining, using, or recovering from the substance
Neglecting responsibilities and social activities
Using substances in risky situations

Causes

  • Changes in brain reward circuitry from repeated substance exposure
  • Genetic vulnerability accounting for 40-60% of risk
  • Environmental factors including peer pressure and early exposure
  • Mental health conditions contributing to self-medication
  • Chronic stress and trauma

Risk Factors

  • Family history of addiction
  • Mental health disorders such as depression, anxiety, or PTSD
  • Early age of first substance use
  • Lack of social support or family involvement
  • Peer pressure and environmental exposure
  • History of childhood trauma or adverse experiences

Diagnosis

  • Clinical interview using DSM-5 criteria for severity classification
  • Screening tools such as CAGE, AUDIT, or DAST questionnaires
  • Urine or blood drug screening
  • Assessment of co-occurring mental health disorders

Treatment

  • Behavioral therapies including CBT and motivational interviewing
  • Medication-assisted treatment such as methadone, buprenorphine, or naltrexone for opioid use disorder
  • Medically supervised detoxification
  • Residential or outpatient rehabilitation programs
  • 12-step programs and peer support groups
  • Treatment of co-occurring mental health conditions

Prevention

  • Education about risks of substance use, especially for adolescents
  • Early intervention for mental health issues
  • Building strong family bonds and social support
  • Community-based prevention programs

When to See a Doctor

  • Inability to stop using a substance despite wanting to
  • Substance use causing problems at work, school, or in relationships
  • Physical withdrawal symptoms when stopping use
  • Feeling that you need to use more of a substance to get the same effect

Frequently Asked Questions

Related Conditions

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Medical Disclaimer: This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider.

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