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Amino AcidModerate Evidence

L-Glutamine

The most abundant amino acid in the body, serving as primary fuel for intestinal enterocytes and immune cells. Essential for gut lining integrity and widely used in leaky gut protocols.

Known Health Benefits

Gut lining repair and intestinal integrity
Primary fuel for immune cells
Muscle recovery and exercise-induced gut symptoms
May support IBS and IBD symptoms

Active Compounds

L-glutamine

Dosage Guidance

5–20 g daily in divided doses

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

Generally very safe; avoid in hepatic encephalopathy; mild GI upset rarely

Known Drug Interactions

May interact with lactulose; caution in certain cancers (glutamine as tumor fuel debated)

Evidence Classification

Moderate Evidence

Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.

Related Entries

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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.