InfectiousICD-10: B50-B54Around 249 million cases globally per year (WHO, 2022)

Malaria

Malaria is a life-threatening mosquito-borne disease caused by Plasmodium parasites transmitted through the bite of infected Anopheles mosquitoes. Symptoms typically appear 10–15 days after the infective bite and include high fever, chills, and flu-like illness. Without prompt treatment, severe malaria can lead to organ failure and death.

At a Glance

Common symptoms
High fever and chills, Profuse sweating, Headache
Main treatments
Artemisinin-based combination therapy (ACT), Chloroquine for P. vivax in sensitive areas, Intravenous artesunate for severe malaria
Category
Infectious · Around 249 million cases globally per year (WHO, 2022)
See a doctor if
Fever developing during or after travel to a malaria-endemic area

Symptoms

High fever and chills
Profuse sweating
Headache
Nausea and vomiting
Muscle and joint pain
Fatigue and malaise
Abdominal pain
Diarrhea
Anemia
Jaundice

Causes

  • Plasmodium falciparum, P. vivax, P. ovale, or P. malariae parasites
  • Bite from infected female Anopheles mosquito
  • Blood transfusion from an infected donor
  • Congenital transmission from mother to child

Risk Factors

  • Travel to or residence in tropical and subtropical regions
  • Lack of access to insecticide-treated bed nets
  • Young children and pregnant women
  • Weakened or absent immunity to malaria
  • Lack of preventive antimalarial medication

Diagnosis

  • Rapid diagnostic test (RDT) for malaria antigens
  • Microscopic examination of blood smear
  • Polymerase chain reaction (PCR) testing
  • Complete blood count showing anemia and thrombocytopenia

Treatment

  • Artemisinin-based combination therapy (ACT)
  • Chloroquine for P. vivax in sensitive areas
  • Intravenous artesunate for severe malaria
  • Supportive care including IV fluids and antipyretics
  • Primaquine to prevent relapse of P. vivax and P. ovale

Prevention

  • Use insecticide-treated mosquito nets while sleeping
  • Apply DEET-based insect repellent to exposed skin
  • Take prophylactic antimalarial medication when traveling
  • Wear long sleeves and pants during dusk and dawn
  • Support indoor residual spraying programs

When to See a Doctor

  • Fever developing during or after travel to a malaria-endemic area
  • Cyclical fevers with severe chills and sweating
  • Signs of confusion, seizures, or difficulty breathing
  • Dark or reduced urine output suggesting kidney involvement

Frequently Asked Questions

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