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DermatologicalICD-10: L80Affects approximately 0.5-2% of the global population

Vitiligo

Also known as: Leukoderma

Vitiligo is a chronic skin condition in which the cells that produce melanin (melanocytes) are destroyed, leading to irregular white patches on the skin. It can affect any area of the body and occurs in all skin types, though it is more noticeable in darker skin tones. While vitiligo is not medically dangerous, it can have significant psychological and emotional effects.

Symptoms

Patchy loss of skin color, typically on the face, hands, arms, and feet
Premature graying or whitening of hair, eyelashes, eyebrows, or beard
Loss of color in the tissues inside the mouth and nose
Change in color of the retina
Patches that may spread or remain stable over time

Causes

  • Autoimmune destruction of melanocytes
  • Genetic predisposition with multiple genes involved
  • Possible environmental triggers such as sunburn or chemical exposure
  • Oxidative stress damaging melanocytes

Risk Factors

  • Family history of vitiligo or other autoimmune conditions
  • Personal history of autoimmune diseases such as thyroid disease or alopecia areata
  • Onset typically before age 30

Diagnosis

  • Physical examination of skin under natural and Wood's lamp light
  • Skin biopsy to confirm absence of melanocytes
  • Blood tests to check for associated autoimmune conditions such as thyroid disease
  • Eye examination to rule out uveitis

Treatment

  • Topical corticosteroids to help restore color in early patches
  • Topical calcineurin inhibitors such as tacrolimus for facial vitiligo
  • Narrowband UVB phototherapy
  • Combination of psoralen and UVA therapy (PUVA)
  • Surgical options including skin grafting for stable vitiligo
  • Depigmentation therapy for extensive vitiligo covering more than 50% of the body

Prevention

  • No known prevention due to autoimmune and genetic basis
  • Sun protection to prevent sunburn on depigmented skin
  • Managing stress which may trigger or worsen the condition

When to See a Doctor

  • New white patches appearing on the skin
  • Existing patches that are spreading or increasing in size
  • Emotional distress related to skin appearance changes
  • For evaluation of associated autoimmune conditions

Frequently Asked Questions

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Medical Disclaimer: This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider.

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