Vitiligo
Also known as: Leukoderma
Vitiligo is a chronic skin condition in which the cells that produce melanin (melanocytes) are destroyed, leading to irregular white patches on the skin. It can affect any area of the body and occurs in all skin types, though it is more noticeable in darker skin tones. While vitiligo is not medically dangerous, it can have significant psychological and emotional effects.
Symptoms
Causes
- Autoimmune destruction of melanocytes
- Genetic predisposition with multiple genes involved
- Possible environmental triggers such as sunburn or chemical exposure
- Oxidative stress damaging melanocytes
Risk Factors
- Family history of vitiligo or other autoimmune conditions
- Personal history of autoimmune diseases such as thyroid disease or alopecia areata
- Onset typically before age 30
Diagnosis
- Physical examination of skin under natural and Wood's lamp light
- Skin biopsy to confirm absence of melanocytes
- Blood tests to check for associated autoimmune conditions such as thyroid disease
- Eye examination to rule out uveitis
Treatment
- Topical corticosteroids to help restore color in early patches
- Topical calcineurin inhibitors such as tacrolimus for facial vitiligo
- Narrowband UVB phototherapy
- Combination of psoralen and UVA therapy (PUVA)
- Surgical options including skin grafting for stable vitiligo
- Depigmentation therapy for extensive vitiligo covering more than 50% of the body
Prevention
- No known prevention due to autoimmune and genetic basis
- Sun protection to prevent sunburn on depigmented skin
- Managing stress which may trigger or worsen the condition
When to See a Doctor
- New white patches appearing on the skin
- Existing patches that are spreading or increasing in size
- Emotional distress related to skin appearance changes
- For evaluation of associated autoimmune conditions
Frequently Asked Questions
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