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Amino AcidModerate Evidence

Glycine

The simplest amino acid with outsized health roles: sleep quality, collagen synthesis, neurotransmission (inhibitory), and glutathione production. Consistently underappreciated.

Known Health Benefits

Improves sleep quality (3g before bed)
Collagen synthesis (major constituent)
Inhibitory neurotransmitter in spinal cord
Supports detoxification via glutathione

Active Compounds

Glycine (aminoacetic acid)

Dosage Guidance

3–5 g before bed for sleep; higher doses for collagen support

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

Generally very safe; mild GI effects at high doses

Known Drug Interactions

May interact with clozapine and antipsychotic medications

Evidence Classification

Moderate Evidence

Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.

Related Entries

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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.