Melatonin
A hormone naturally produced by the pineal gland to regulate the sleep-wake cycle. The most widely used sleep supplement globally, with strong evidence for circadian rhythm disorders.
Known Health Benefits
Active Compounds
N-acetyl-5-methoxytryptamine
Dosage Guidance
0.5–3 mg 30–60 minutes before bed (lower doses often as effective as higher)
Always consult a healthcare provider for personalized dosing.
Potential Side Effects
Drowsiness, vivid dreams, headache; may affect hormonal systems with long-term high doses
Known Drug Interactions
May interact with blood thinners, diabetes medications, immunosuppressants, and sedatives
Evidence Classification
Supported by randomized controlled trials (RCTs), systematic reviews, or meta-analyses published in peer-reviewed journals.
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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.