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CompoundModerate Evidence

NAD+ (Nicotinamide Riboside)

Nicotinamide Riboside

Nicotinamide Riboside (NR) is a vitamin B3 derivative that raises NAD+ levels, supporting mitochondrial biogenesis, cellular energy, and healthy aging via sirtuin activation.

Known Health Benefits

Increases cellular NAD+ levels
Mitochondrial biogenesis and energy
Healthy aging and longevity support
Neuroprotective potential

Active Compounds

Nicotinamide riboside (NIAGEN), nicotinamide riboside chloride

Dosage Guidance

250–500 mg daily

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

Generally well tolerated; flushing less common than niacin; mild GI effects

Known Drug Interactions

May interact with chemotherapy; high niacin intake may interfere with conversion

Evidence Classification

Moderate Evidence

Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.

Related Entries

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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.