St. John's Wort
Hypericum perforatum
The most studied herbal antidepressant, with meta-analyses showing efficacy comparable to SSRIs for mild-to-moderate depression. Modulates serotonin, dopamine, and norepinephrine.
Known Health Benefits
Active Compounds
Hypericin, hyperforin, flavonoids, xanthones
Potential Side Effects
Photosensitivity, GI upset, dizziness; may trigger mania in bipolar disorder
Known Drug Interactions
MAJOR interactions with SSRIs (serotonin syndrome), birth control, blood thinners, HIV medications, and many other drugs via CYP450 induction
Evidence Classification
Supported by randomized controlled trials (RCTs), systematic reviews, or meta-analyses published in peer-reviewed journals.
Related Entries
Have questions about St. John's Wort?
Ask Mother Nature AI about dosing, interactions with your medications, whether it fits your health goals, and more — personalized to your health profile.
This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.