SAM-e
S-adenosyl-L-methionine
A naturally occurring compound involved in methylation reactions throughout the body. Studied for depression (comparable to TCAs in meta-analyses), liver health, and joint pain.
Known Health Benefits
Active Compounds
S-adenosyl-L-methionine
Potential Side Effects
GI upset, anxiety, insomnia; may trigger mania in bipolar disorder — contraindicated
Known Drug Interactions
MAJOR interaction with antidepressants (serotonin syndrome risk); interacts with levodopa
Evidence Classification
Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.
Related Entries
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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.