Vitamin B12
Cobalamin
Essential for nervous system function, DNA synthesis, and red blood cell formation. Deficiency is common in vegans, vegetarians, older adults, and those on metformin.
Known Health Benefits
Active Compounds
Methylcobalamin, cyanocobalamin, adenosylcobalamin, hydroxocobalamin
Dosage Guidance
500–1000 mcg daily (sublingual methylcobalamin preferred for deficiency)
Always consult a healthcare provider for personalized dosing.
Potential Side Effects
Generally very safe at normal doses; rare skin reactions with injections
Known Drug Interactions
Metformin, PPIs, and H2 blockers significantly reduce absorption over time
Evidence Classification
Supported by randomized controlled trials (RCTs), systematic reviews, or meta-analyses published in peer-reviewed journals.
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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.