Folate
Vitamin B9
Essential B vitamin critical for cell division, DNA synthesis, and neural tube development. MTHFR gene variants affect ~40% of the population, making methylfolate (5-MTHF) the preferred form.
Known Health Benefits
Active Compounds
5-methyltetrahydrofolate (5-MTHF), folic acid, folinic acid
Potential Side Effects
May mask B12 deficiency at high doses; possible concern with unmetabolized folic acid
Known Drug Interactions
Methotrexate, phenytoin, and sulfasalazine may deplete or block folate
Evidence Classification
Supported by randomized controlled trials (RCTs), systematic reviews, or meta-analyses published in peer-reviewed journals.
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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.