Gout
Also known as: Gouty Arthritis, Crystal Arthritis
Gout is a form of inflammatory arthritis caused by the buildup of uric acid crystals in the joints, most commonly affecting the big toe. It causes sudden, severe attacks of pain, swelling, redness, and tenderness. With proper management including medication and dietary modifications, gout flares can be prevented and joint damage avoided.
Symptoms
Causes
- Hyperuricemia (elevated uric acid in the blood)
- Overproduction of uric acid by the body
- Decreased kidney excretion of uric acid
- Deposition of monosodium urate crystals in joints
Risk Factors
- Male sex
- Obesity and high-purine diet (red meat, organ meats, shellfish)
- Excessive alcohol consumption, especially beer
- Chronic kidney disease
- Certain medications (diuretics, low-dose aspirin)
- Family history of gout
Diagnosis
- Joint fluid analysis showing urate crystals under polarized microscopy
- Serum uric acid level measurement
- X-ray to rule out other conditions and detect joint damage
- Dual-energy CT scan to detect urate deposits
- Ultrasound showing double contour sign
Treatment
- Colchicine or NSAIDs for acute flare management
- Corticosteroids for patients who cannot tolerate NSAIDs or colchicine
- Urate-lowering therapy: allopurinol or febuxostat
- Uricosuric agents (probenecid) to increase uric acid excretion
- Pegloticase infusions for severe, refractory gout
- Dietary modifications to reduce purine intake
Prevention
- Limit intake of high-purine foods
- Reduce alcohol consumption, especially beer and spirits
- Stay well hydrated with water
- Maintain a healthy weight
- Take urate-lowering medications consistently if prescribed
When to See a Doctor
- You experience sudden, severe joint pain and swelling
- Joint pain is accompanied by fever
- Gout flares are becoming more frequent
- You notice hard lumps (tophi) forming around joints
Frequently Asked Questions
Related Conditions
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Vitamin C
StrongVitamin · Immune support and white blood cell function
Turmeric
StrongHerb · Reduces systemic inflammation (NF-κB pathway)
Omega-3 (EPA/DHA)
StrongFatty Acid · Cardiovascular health (TG reduction, anti-arrhythmic)
These supplements have been studied in relation to Gout. Always consult your healthcare provider before starting any supplement, especially if you take medications.
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