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AdaptogenModerate Evidence

Ashwagandha

Withania somnifera

A powerful adaptogen used in Ayurvedic medicine for stress reduction, cognitive enhancement, and hormonal balance. One of the most clinically studied adaptogens with multiple human RCTs supporting its effects.

Known Health Benefits

Reduces cortisol and perceived stress
Improves sleep quality and onset
Supports thyroid function
Enhances cognitive performance and memory

Active Compounds

Withanolides, withaferin A, sitoindosides, alkaloids

Dosage Guidance

300–600 mg standardized root extract daily

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

May cause drowsiness, upset stomach, or thyroid changes at high doses. Not recommended during pregnancy.

Known Drug Interactions

May enhance effects of sedatives, thyroid medications, and immunosuppressants

Evidence Classification

Moderate Evidence

Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.

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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.