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CompoundModerate Evidence

MSM (Methylsulfonylmethane)

An organic sulfur compound widely used for joint health and inflammation reduction, with evidence for joint pain, oxidative stress, and collagen synthesis support.

Known Health Benefits

Joint pain and stiffness reduction
Anti-inflammatory (NF-κB inhibition)
Collagen synthesis support via sulfur
Antioxidant properties

Active Compounds

Methylsulfonylmethane (dimethyl sulfone)

Dosage Guidance

1–3 g daily

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

Generally well tolerated; GI upset, headache initially (detox reaction)

Known Drug Interactions

May interact with blood thinners

Evidence Classification

Moderate Evidence

Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.

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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.