Skip to main content
CompoundModerate Evidence

Resveratrol

A polyphenol found in red wine, grapes, and berries that activates SIRT1 sirtuins and AMPK, studied for cardiovascular protection, anti-aging, and metabolic health.

Known Health Benefits

Sirtuin (SIRT1) activation for longevity
Cardiovascular and endothelial protection
Anti-aging and anti-inflammatory properties
Blood sugar and metabolic support

Active Compounds

Trans-resveratrol, cis-resveratrol, piceatannol, pterostilbene

Dosage Guidance

100–500 mg trans-resveratrol daily

Always consult a healthcare provider for personalized dosing.

Potential Side Effects

GI upset at high doses; potential estrogen-like effects at very high doses

Known Drug Interactions

May interact with blood thinners, NSAIDs, and CYP3A4 substrates

Evidence Classification

Moderate Evidence

Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.

Related Entries

Have questions about Resveratrol?

Ask Mother Nature AI about dosing, interactions with your medications, whether it fits your health goals, and more — personalized to your health profile.

This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.