MetabolicVery common; estimated to affect a large share of adults in Western countries, often without diagnosis

Insulin Resistance

Also known as: Impaired insulin sensitivity

Insulin resistance is a condition in which the body's cells, particularly in muscle, fat and the liver, stop responding properly to insulin, the hormone that moves glucose from the blood into cells for energy. To compensate, the pancreas produces more and more insulin, which can keep blood sugar normal for years. Over time the pancreas may not keep up, blood sugar rises, and prediabetes or type 2 diabetes develops. Insulin resistance is also at the root of metabolic syndrome and is linked to fatty liver disease, polycystic ovary syndrome, high blood pressure and heart disease. It is driven mainly by excess abdominal fat, inactivity and genetics, and it responds very well to weight loss, exercise and dietary change.

At a Glance

Common symptoms
Often no symptoms in the early stages, Increased hunger, cravings for sweets and weight gain, especially around the waist, Fatigue, particularly after meals
Main treatments
Weight loss, even 5 to 10 percent of body weight, which substantially improves insulin sensitivity, Regular aerobic exercise plus resistance training, which increases muscle glucose uptake for hours after each session, A diet based on vegetables, whole grains, legumes, lean protein and healthy fats while cutting sugary drinks, refined carbohydrates and processed foods
Category
Metabolic · Very common; estimated to affect a large share of adults in Western countries, often without diagnosis
See a doctor if
You are overweight with a large waist, a family history of diabetes, or other risk factors and have not had your blood sugar checked

Symptoms

Often no symptoms in the early stages
Increased hunger, cravings for sweets and weight gain, especially around the waist
Fatigue, particularly after meals
Difficulty losing weight despite effort
Dark, velvety skin patches on the neck, armpits or groin (acanthosis nigricans)
Skin tags
In women, irregular periods or features of polycystic ovary syndrome

Causes

  • Excess body fat, particularly visceral fat around the abdominal organs, which releases substances that interfere with insulin signalling
  • Physical inactivity, since muscle contraction is a major driver of glucose uptake
  • A diet high in refined carbohydrates, added sugars and ultra-processed foods
  • Genetic factors affecting insulin signalling and fat storage
  • Chronic inflammation and elevated stress hormones such as cortisol
  • Sleep deprivation and sleep apnea

Risk Factors

  • Being overweight, with a waist circumference above 40 inches (102 cm) in men or 35 inches (88 cm) in women
  • A family history of type 2 diabetes
  • A sedentary lifestyle
  • Polycystic ovary syndrome or a history of gestational diabetes
  • Certain medications, including corticosteroids and some antipsychotics
  • Smoking and poor sleep

Diagnosis

  • There is no single routine test; diagnosis is based on risk factors, examination and blood results
  • Fasting glucose and HbA1c to detect prediabetes or diabetes
  • Fasting insulin or the HOMA-IR calculation in some settings, though these are not standardized for routine use
  • Lipid profile, often showing high triglycerides and low HDL cholesterol
  • Blood pressure, waist measurement and liver tests, which help identify associated metabolic syndrome or fatty liver

Treatment

  • Weight loss, even 5 to 10 percent of body weight, which substantially improves insulin sensitivity
  • Regular aerobic exercise plus resistance training, which increases muscle glucose uptake for hours after each session
  • A diet based on vegetables, whole grains, legumes, lean protein and healthy fats while cutting sugary drinks, refined carbohydrates and processed foods
  • Medications such as metformin when blood sugar is already raised or risk is high, prescribed by your doctor
  • Treating associated conditions such as high blood pressure, high cholesterol, sleep apnea or PCOS
  • Supportive: improving sleep duration and quality and managing stress
  • Supportive: stopping smoking and limiting alcohol

Prevention

  • Keep your waist size and body weight within a healthy range
  • Be active every day and sit less; even short walks after meals help
  • Build and maintain muscle with strength training
  • Limit sugary drinks, sweets and refined grains, and eat plenty of fibre
  • Prioritize 7 to 9 hours of sleep
  • Have regular checks of blood sugar, blood pressure and cholesterol if you have risk factors

When to See a Doctor

  • You are overweight with a large waist, a family history of diabetes, or other risk factors and have not had your blood sugar checked
  • Dark, velvety patches of skin or multiple skin tags appear
  • Increased thirst, frequent urination or unexplained fatigue
  • Irregular periods, excess facial hair or difficulty conceiving, which may indicate PCOS
  • You want support with a structured weight loss or exercise plan

Frequently Asked Questions

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