Berberine
A plant alkaloid with metabolic effects comparable to metformin in multiple clinical trials, activating AMPK to regulate blood sugar, lipids, and gut microbiome. One of the most impressive natural metabolic compounds.
Known Health Benefits
Active Compounds
Berberine hydrochloride (from Berberis, Goldenseal, Oregon Grape)
Dosage Guidance
500 mg 2–3x daily with meals
Always consult a healthcare provider for personalized dosing.
Potential Side Effects
GI discomfort, nausea, constipation or diarrhea common initially; start low and increase
Known Drug Interactions
MAJOR: significantly enhances metformin and diabetes medications; inhibits CYP2D6, CYP3A4 — many drug interactions
Evidence Classification
Supported by randomized controlled trials (RCTs), systematic reviews, or meta-analyses published in peer-reviewed journals.
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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.