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DigestiveICD-10: K58Affects approximately 10–15% of the global population

Irritable Bowel Syndrome (IBS)

Also known as: IBS, Spastic Colon, Nervous Stomach

IBS is a common functional gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits without identifiable structural abnormality. It is classified as IBS-C (constipation), IBS-D (diarrhea), or IBS-M (mixed). While not life-threatening, IBS significantly affects quality of life.

Symptoms

Recurrent abdominal pain associated with bowel movements
Bloating and abdominal distension
Alternating diarrhea and constipation
Mucus in the stool
Urgency to have a bowel movement
Feeling of incomplete evacuation
Symptoms worsening with stress or certain foods
Gas and flatulence

Causes

  • Gut-brain axis dysfunction
  • Visceral hypersensitivity
  • Altered gut motility
  • Intestinal microbiome imbalances
  • Post-infectious IBS following gastroenteritis
  • Psychological factors including stress and anxiety

Risk Factors

  • Female sex (twice as common in women)
  • Age under 50
  • Family history of IBS
  • History of anxiety, depression, or emotional trauma
  • Previous gastrointestinal infection

Diagnosis

  • Rome IV criteria assessment
  • Exclusion of alarm features (weight loss, bleeding, anemia)
  • Blood tests including CBC, CRP, and celiac serology
  • Stool tests to rule out infection and inflammation
  • Colonoscopy if alarm features are present or patient is over 45

Treatment

  • Dietary modifications: low-FODMAP diet, increased fiber for IBS-C
  • Antispasmodic medications
  • Laxatives for IBS-C or anti-diarrheals for IBS-D
  • Prescription medications: linaclotide for IBS-C; rifaximin for IBS-D
  • Low-dose tricyclic antidepressants or SSRIs for pain modulation
  • Cognitive behavioral therapy and gut-directed hypnotherapy

Prevention

  • Identify and avoid food triggers
  • Eat regular, balanced meals
  • Exercise regularly
  • Manage stress through mindfulness or therapy

When to See a Doctor

  • Symptoms significantly interfere with daily life
  • You experience weight loss, rectal bleeding, or persistent vomiting
  • Symptoms begin after age 50
  • Family history of colorectal cancer or IBD

Frequently Asked Questions

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