5-HTP (5-Hydroxytryptophan)
5-Hydroxytryptophan
A direct amino acid precursor to serotonin and melatonin, derived from Griffonia simplicifolia seeds. Studied for depression, anxiety, sleep quality, and appetite regulation.
Known Health Benefits
Active Compounds
5-hydroxytryptophan (from Griffonia simplicifolia)
Dosage Guidance
50–300 mg daily (start at 50 mg, take with food)
Always consult a healthcare provider for personalized dosing.
Potential Side Effects
Nausea, GI upset; eosinophilia-myalgia syndrome risk with impure sources
Known Drug Interactions
MAJOR: serotonin syndrome risk when combined with SSRIs, SNRIs, MAOIs, or triptans — do not combine without physician guidance
Evidence Classification
Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.
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This entry is for educational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement regimen, especially if you take medications or have health conditions.