Shiitake
Lentinula edodes
One of the most consumed medicinal mushrooms globally, shiitake contains lentinan (used in Japanese oncology as an approved immunotherapy adjunct) and is widely studied for immune function and cardiovascular health.
Known Health Benefits
Active Compounds
Lentinan, eritadenine, beta-glucans, ergothioneine, sterol compounds
Potential Side Effects
Raw or undercooked mushroom: 'flagellate dermatitis' in sensitive individuals; safe when cooked
Known Drug Interactions
May interact with blood thinners and immunosuppressants
Evidence Classification
Supported by cohort studies, case-control studies, or multiple observational studies with consistent findings.
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